Professional and Research Experience:
2019- Distinguished Chair Professor, Institute for Translation Research in Biomedicine (ITRBM), Chang Gung Memorial Hospital, Kaohsiung, Taiwan
2011-19 Chair Professor, ITRBM, Chang Gung Memorial Hospital, Kaohsiung, Taiwan
2012-17 Director, Department of Medical Research, Chang Gung Memorial Hospital, Kaohsiung, Taiwan
2007-11 Head, Division of Basic Medical Research, Veterans General Hospital, Kaohsiung, Taiwan
1998-11 Senior Principal Investigator, 1996-98 Senior Principal Investigator, 1990-96 Principal Investigator, Department of Medical Research, Veterans General Hospital, Taipei, Taiwan
Major Honors:
2002-05 Convener, Physiology Study Section, National Science Council, Taiwan
2003- Associate Editor, Journal of Biomedical Sciences
2011-15 President, 2005-11 Vice-President, Federation of Asian and Oceanian Physiological Sciences
2007-11 President, Chinese Physiological Society
2017-21 President, 2013-17 Vice-President, International Union of Physiological Sciences
Major Awards:
2000 Outstanding Research Award, Taiwan Pharmacological Society
2000-12 Outstanding Research Award, Executive Yuan, Taiwan
2001 S.C. Wang Outstanding Research Award in Neuroscience, Taiwan
2004-15 Outstanding Research Award, National Science Council, Taiwan
2019 Life-time Achievement Award, Federation of Asian and Oceanian Physiological Societies
Selected Publications: 5 representative papers from 215 publications
Chan SHH, Wang LL, Chang KF, Ou CC, Chan JYH. Altered temporal profile of heat shock factor 1 phosphorylation and heat shock protein 70 expression induced by heat shock in nucleus tractus solitarii of spontaneously hypertensive rats. Circulation, 2003;107:339-345.
Chan SHH, Wu CWJ, Chang AYW, Hsu KS, Chan JYH. Transcriptional upregulation of brain-derived neurotrophic factor in rostral ventrolateral medulla by angiotensin II: Significance in superoxide homeostasis and neural regulation of arterial pressure. Circulation Research, 2010;107:1127-1139.
Chan SHH, Chan JYH. Brain stem NOS and ROS in neural mechanisms of hypertension. Antioxidants and Redox Signaling, 2014;20:146-163.
Chan SHH, Chan JYH. Phosphodiesterase 2 as a therapeutic target for heart failure: is upregulation an option? Circulation Research, 2017;120:13-16.
Chan JYH, Chan SHH. Differential impacts of brain stem oxidative stress and nitrosative stress on sympathetic vasomotor tone. Pharmacology and Therapeutics, 2019;201: 20-136.
Professional and Research Experience:(Begin with the initial professional experience)
Professor, The University of Texas M.D. Anderson Cancer Center, TX, 09/94-02/17/19
Department Chair, Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 3/2000−02/17/19
Ruth Legett Jones Distinguished Chair, The University of Texas MD Anderson Cancer Center, Houston, TX, 1/2003−02/17/19
Director, Center for Biological Pathways, The University of Texas MD Anderson Cancer Center, Houston, TX, 9/2008−02/17/19
Vice President for Basic Research, The University of Texas MD Anderson Cancer Center, Houston, TX, 3/2010−02/17/19
President (International), Society of Chinese Bioscientists in America, 2004−2005
Member, Board of Directors, China Medical University and Hospital Health System, Taiwan, 2004-01/2019.
Member, Review and Selection Committee in the Biopharmaceutical Science Category, Tang Prize, 2013- present.
Overseas Member, Scientific Advisory Board*, Institute of Molecular and Cellular Biology, A*STAR, Singapore, June 1, 2014-May 31, 2018. *Co-chaired by two Nobel Laureates: Drs. Randy Schekman and Thomas Sudhof.
Member, Cancer Research Advisory Board, Ministry of Health and Welfare of Taiwan, April 10, 2014 to December 31, 2017.
Member, Scientific Advisory Board, Life Sciences Institute, Zhejiang University, Hang Zhou, China, 2014- present.
Member, Advisory Committee, University of Macau, Macau, China, July 2015-2016
Member, Selection Committee, Pezcoller Foundation-AACR Award, 2016
Member, External Advisory Board, The University of Kansas Cancer Center, 2017-2019
President, China Medical University, Taichung, Taiwan 02/18/2019- present
Member, Advisory Board, Molecular Cell, Cell Press, 2020
Member, Presidential Science Prize Steering Committee總統科學獎委員會, 2020-2021
Member, National Taiwan University Advisory Committee, 2020-present
Member, Review Committee “Yu-Shan Scholars recruitment program”, Ministry of Education教育部「玉山學者」計畫【醫學】領域審議委員, 2020-present
Member, Academic Advisory Board (AAC), Institute of Molecular Biology, 01/01/2020-12/31/2022 & Biomedical Translation Research Center (BioTReC), National Biotechnology Research Park (NBRP), February 1, 2021 to October 17, 2022. Academia Sinica
Adjunct Researcher, Genomics Research Center, Academia Sinica, 2021
Awards and Honors:( up to five, Begin with the recent honor)
Selected as a candidate of the 2021 Highly Cited Researchers (Clarivate).
John P. McGovern Award for Outstanding Teaching, The University of Texas Health Science Center in Houston, 1990, 1993, 1999 and 2018
The University of Texas M. D. Anderson Cancer Center LeMaistre Outstanding Achievement Award, 2011.
Fellow, Section of Biological Sciences, American Association for the Advancement of Science, AAAS, 2010
Academician (Lifetime), Academia Sinica, Taiwan, 2002
Selected Publications: (up to five, Begin with the recent publication)
154 out of 582 peer-reviewed publications are published in journals which impact factor is 10 or above, of which 65 (48 CNS--Cell, Nature, Science series) serves as a corresponding (first or co-corresponding) author and 89 (62 CNS) as a co-author. 110 out of 154 are published in Cell, Nature, Science series. Life time h-index (Scopus)=127, Google Scholar 155
Jiang Z, Lim SO, Yan M, Hsu JL, Yao J, Wei Y, Chang SS, Yamaguchi H, Lee HH, Ke B, Hsu JM, Chan LC, Hortobagyi GN, Yang L, Lin C, Yu D, Hung MC. Tyro3 induces anti-PD-1/PD-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis. J Clin Invest Apr 15;131(8):139434, 2021. doi: 10.1172/JCI139434.
Liu CX†, Zha Z†, Zhou C†, Chen Y, Xia W, Wang YN, Lee HH, Yin Y, Yan M. Chang CW, Qiu Y, Li H, Li CW, Hsu JM, Hsu JL, Wang SC, Ren N*, Hung MC*. Ribonuclease 7-driven activation of ROS1 is a new potential therapeutic target in hepatocellular carcinoma. J of Hepatology Apr 74(4):907-918, 2021. † Equal contribution; *Co-corresponding authors.
Hou J, Zhao R, Xia W, Chang CW, You Y, Hsu JM, Nie L, Chen Y, Wang YC, Liu C, Wang WJ, Wu Y, Ke B, Hsu JH, Huang K, Ye Z, Yang Y, Xia X, Li Y, Li CW, Shao B, Tainer JA, Hung MC. PD-L1-mediated Gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumor necrosis. Nature Cell Biology, Oct;22(10):1264-1275 (Sept 14 Epub online) 2020.
#*Xu D, #Wang Z, Xia Y, Shao F, Xia W, Wei Y, Li X, Qian X, Lee JH, Du L, Zheng Y, Lv G, Leu JS, Wang H, Xing D, Liang T, *Hung MC, *Lu Z. The gluconeogenic enzyme PCK1phosphorylates INSIG1/2 for lipogenesis. Nature 580(7804):530-535 (Epub April 8) 2020. #equal contribution *co-corresponding authors.
Lee HH, Wang YN, Xia W, Chen CH, Rau KM, Ye L, Chou CK, Wei Y, Wang SC, Yan M, Tu CY, Hsia TC, Chiang SF, Chao KSC, Wistuba II, Hsu JL, Hortobagyi GN, Hung MC. Removal of N-linked glycosylation enhances PD-L1 detection and predicts anti-PD-1/PD-L1 therapeutic efficacy. Cancer Cell 36(2):168-178, (epub online July 18) 2019.
Professional and Research Experience:
1994. ~ 1997. : Postdoctoral Researcher, Oxford University Laboratory of Physiology
1997 ~ 2008 : Lecturer, Assistant Professor, Associate Professor
2007 ~ 2008 : Visiting Scholar of UCSD
2008 ~ Present : Professor
Awards and Honors:
Selected Publications:
Pham DD, Lee YS, Chi S, CH Leem, The mean of fasting, 1-h, and 2-h plasma glucose levels is superior to each separate index in predicting diabetes, Diabetes Res. Clin. Prac. 2021
YK Jeon, JB Youm, K Ha, JH Woo, HY Yoo, CH Leem, SH Lee, SJ Kim Teaching cardiac excitation-contraction coupling using a mathematical computer simulation model of human ventricular myocytes Adv. in Physiol. Edu. 44 (3), 323 – 333 2020
M Hwang, CH Lim, CH Leem, EB Shim In silico models for evaluating proarrhythmic risk of drugs APL bioengineering 4 (2), 3 2020
DD Pham, JH Lee, KH Hong, YJ Jung, SJ Kim, CH Leem Seasonal effects on resting energy expenditure are dependent on age and percent body fat Clinical Nutrition 39 (4), 1276-1283
Professional and Research Experience:
1988-1989 Intern, National Taiwan University Hospital, Taipei, Taiwan
1989-1991 Medical Officer, Chinese Air Forces, Taiwan (mandatory military service)
1997-1999 Instructor of Neuroanatomy at Yale University School of Medicine, New Haven, CT
2001-2007 Assistant Professor, Division of Developmental Biology, Department of Pediatrics,Cincinnati Children's Hospital Medical Center, Cincinnati, OH
2007-2012 Associate Professor (tenured), Division of Developmental Biology and Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
2012-2017 Associate Professor (tenure-track 2012-2015; tenured 2015-2017), Department of Pediatrics, Division of Neurology, Emory University School of Medicine, Atlanta, GA
2014-2017 Director of Research, Division of Neurology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA
2018-Present Professor, Department of Neuroscience, University of Virginia School of Medicine, Charlottesville, VA
Selected Publications:
http://www.ncbi.nlm.nih.gov/pubmed/?term=Kuan+Rakic+P+or+Chia-Yi+Kuan
Professional and Research Experience:
2000 – 2020
Program Director
Postdoctoral Training Program in Clinical Chemistry, Laboratory Medicine and Pathobiology, University of Toronto
2013 – 2018
Chair
Communications and Publications Division, International Federation of Clinical Chemistry and Laboratory Medicine (IFCC)
1998 – 2002
Associate Scientist
Structural Biology & Biochemistry/Cardiovascular Diseases, Research Institute, the Hospital for Sick Children
1998 – 2001
Associate Professor
Laboratory Medicine and Pathobiology, University of Toronto
1995
Visiting Professor
Department of Clinical Biochemistry, University of Gothenburg, Sweden
1994 – 1998
Program Director
Graduate and Postdoctoral Training Program in Clinical Chemistry, Department of Chemistry and Biochemistry, University of Windsor
1993 – 1998
Adjunct Associate Professor
Pathology, School of Medicine, Wayne State University
1992 – 1998
Associate Professor (Tenured)
Chemistry and Biochemistry, University of Windsor – Tenure awarded in 1992
1998 – 1992
Assistant Professor
Chemistry and Biochemistry, University of Windsor
Awards and Honors:
Lifetime Achievement Award, Faculty of Medicine, University of Ottawa.
Richard G. Hegele Award for Excellence in Research and Innovation
AACC Norman P. Kubasik Award
AACC Academy Outstanding Research Award
Hungarian Society of Laboratory Medicine Award
Selected Publications:
1. Bohn MK, Yousef P, Steele S, Sepiashvili L, Adeli K. Multi-Inflammatory Syndrome in Children: A View into Immune Pathogenesis from a Laboratory Perspective. J Appl Lab Med. Epub 2021 Aug 31. doi:10.1093/jalm/jfab114. PubMed PMID: 34463724.
2. Wilson S, Bohn MK, Adeli K. POCT: An Inherently Ideal Tool in Pediatric Laboratory Medicine. EJIFCC. 2021 Jun 29;32(2):145-157. PubMed PMID: 34421483.
3. Wilson S, Bohn MK, Hall A, Higgins V, Abdelhaleem M, Adeli K. Continuous reference curves for common hematology markers in the CALIPER cohort of healthy children and adolescents on the Sysmex XN-3000 system. Int J Lab Hematol. Epub 2021 Aug 1. doi: 10.1111/ijlh.13670. PubMed PMID: 34333858.
4. Ghazizadeh H, Kathryn Bohn M, Yaghooti-Khorasani M, Kamel Khodabandeh A, Zare-Feyzabadi R, Timar A, Mohammadi-Bajgiran M, Oladi MR, Rohban M, Esmaily H, Ferns GA, Adeli K, Ghayour-Mobarhan M. Age- and sex-specific reference intervals for superoxide dismutase enzyme and several minerals in a healthy adult cohort. J Clin Lab Anal. 2021 Sep;35(9):e23897. doi: 10.1002/jcla.23897. PubMed PMID:34273186.
5. Bohn MK, Wilson S, Hall A, Adeli K. Pediatric reference interval verification for endocrine and fertility hormone assays on the Abbott Alinity system. Clin Chem Lab Med. 2021 Jun 30;59(10):1680-1687. doi:10.1515/cclm-2021-0337. PubMed PMID: 34187103.
Professional and Research Experience:
Post-doctoral training including residency/fellowship:
11/1992-11/1995
Resident in Pediatrics, Assistance Publique-Hôpitaux de Paris, France, EU
11/1995-09/1999
Clinical and Research Fellow, Pediatric Immunology and Hematology (Heads: Claude Griscelli and Alain Fischer), Necker Hospital for Sick Children and School of Medicine, Assistance Publique-Hôpitaux de Paris, Paris Descartes University, France, EU
Academic positions:
11/1995-09/1999
Research Fellow, Laboratory of Primary Immunodeficiencies (Head: A. Fischer), Necker Hospital for Sick Children and School of Medicine, Paris Descartes University, Paris, France, EU
09/1999-09/2008
Professor of Pediatric Hematology, Pediatric Immunology and Hematology Unit (Head: A. Fischer), Necker Hospital for Sick Children and School of Medicine, Paris Descartes University, Paris, France, EU
09/2000-09/2008
Head of Laboratory (with Laurent Abel), Laboratory of Human Genetics of Infectious Diseases, Necker Hospital for Sick Children and School of Medicine, Paris Descartes University, Paris, France, EU
09/2008-
Professor, The Rockefeller University, New York, USA
09/2008-
Head of Laboratory, St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, USA
09/2008-
Professor, University of Paris, Paris, France, EU
Head of Laboratory (with Laurent Abel), Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Imagine Institute, INSERM and University of Paris, France, EU
02/2014-
Investigator, Howard Hughes Medical Institute, New York, USA
12/2020-
Levy Family Professor, The Rockefeller University, New York, USA
Awards and Honors:
1992 Jean-Marie Dubert Prize for PhD Thesis in Immunology, Universités de Paris, France, EU
1994 Médaille d´Or de l´Internat en Médecine des hôpitaux de Paris, France, EU
1995 Pierre Robin Prize for MD Thesis, Chancellerie des Universités de Paris, France, EU
2000-2008 Junior Member, Institut Universitaire de France, France, EU
2001 Laureate, Schlumberger Foundation for Education and Research, France, EU
2003-2019 Member, Inborn Errors of Immunity Committee, International Union of Immunological Societies
2004 International Lucien Dautrebande Prize (Medicine), Royal Academy of Medicine, Belgium, EU
2005- Member, European Molecular Biology Organization
2005 Jacques Oudin Prize, Société Française d’Immunologie, France, EU
2005-2008 International Scholar, Howard Hughes Medical Institute
2006-2010 President, European Society for Primary Immunodeficiencies
2008 Richard Lounsbery Award, French Academy of Sciences, National Academy of Sciences USA
2008- Foreign Associate, American Society for Clinical Investigation
2008 AGF-Institut de France Prize, AGF Foundation and Institut de France, France, EU
2009 Doctor Honoris Causa, University of Zürich, Switzerland
2009 Oswald Avery Award, Infectious Diseases Society of America
2009- Member, The Practitioners' Society of New York
2010 E. Mead Johnson Award for Research in Pediatrics, Society for Pediatric Research
2010 Doctor Honoris Causa, University of Debrecen, Hungary
2011 InBev-Baillet Latour Health Prize, Immunology and Infectious Diseases, Belgium, EU
2012 Ilse and Helmut Wachter Foundation Award, Innsbruck Medical University, Austria, EU
2012 Seymour and Vivian Milstein Award, International Cytokine & Interferon Society
2014 Norman J. Siegel New Member Outstanding Science Award, American Pediatric Society
2014 Presidential Award, Clinical Immunology Society
2014 Robert Koch Prize, Germany, EU
2014 Member Honoris Causa, Scandinavian Society for Immunology
2014 Sanofi-Institut Pasteur International Mid-Career Award, France, EU
2015-2022 President, Henry Kunkel Society
2015- Foreign Associate, National Academy of Sciences, USA
2015- International Member, National Academy of Medicine, USA
2016 Stanley J. Korsmeyer Award, American Society for Clinical Investigation
2016 Grand Prix, Institut National de la Santé et de le Recherche Médicale, France, EU
2017 Steinman Award for Human Immunology Research, American Association of Immunologists
2018 Distinguished Service Award, Clinical Immunology Society
2018 Honorary Skou Professor, Aarhus University, Denmark, EU
2019 Grand Prix Claude Bernard, Paris, France, EU
2019 Thomas A. Waldmann Award for Excellence in Human Immunology, Foundation for Primary Immunodeficiency Diseases
2019 Honorary Member, Interurban Clinical Club
2019 Boyle Scientific Achievement Award, Immune Deficiency Foundation
2020- Member, Association of American Physicians
2020- Chevalier de l’ordre de la Légion d’Honneur, France, EU
2021- Member, Royal Academy of Medicine, Belgium, EU
2021 Doctor JuanAbarca International Award of Medical Sciences, Spain, EU
2022 Doctor Honoris Causa, Katholieke Universiteit Leuven, Belgium, EU
Selected Publications:
Béziat, V. et al. Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy. Cell 184, 3812–3828.e30 (2021).
Yang, R. et al. Human T-bet Governs Innate and Innate-like Adaptive IFN-γ Immunity against Mycobacteria. Cell 183, 1826–1847.e31 (2020).
Bastard, P. et al. Autoantibodies against type I IFNs in patients with life-threatening COVID-19. Science 370, eabd4585 (2020).
Zhang, Q. et al. Inborn errors of type I IFN immunity in patients with life-threatening COVID-19. Science 370, eabd4570 (2020).
Casanova, J.-L. et al. A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection. Cell 181, 1194–1199 (2020).
Professional and Research Experience:
Institute of Pharmacology, NTU; Assistant professor, 2011-2016.
Institute of Pharmacology, NTU; Associate professor, 2016-present.
Awards and Honors:
台灣大學醫學院青杏獎 (2016)
台灣大學教學傑出獎 (2020)
Selected Publications:
Yang KC, Chuang KW, Yen WS, Lin SY, Chen HH, Chang SW, Lin YS, Wu WL, Tsao YP, Chen WP*, Chen SL (2019) Deficiency of nuclear receptor interaction protein leads to cardiomyopathy by disrupting sarcomere structure and mitochondrial respiration. J Mol Cell Cardiol 137: 9-24. (* Corresponding author)
Fan SM, Chang YT, Chen CL, Wang WH, Pan MK, Chen WP, Huang WY, Xu Z, Huang HE, Chen T, Plikus MV, Chen SK, Lin SJ. External light activates hair follicle stem cells through eyes via an ipRGC-SCN-sympathetic neural pathway. Proc Natl Acad Sci U S A. 2018;115(29):E6880-E6889.
Ho YS, Tsai WH, Lin FC, Huang WP, Lin LC, Wu SM, Liu YR and Chen WP*. Cardioprotective Actions of TGFbetaRI Inhibition Through Stimulating Autocrine/Paracrine of Survivin and Inhibiting Wnt in Cardiac Progenitors. Stem cells. 2016;34:445-55. (*corresponding author)
Chen WP*, Liu YH, Ho YJ and Wu SM. Pharmacological inhibition of TGFbeta receptor improves Nkx2.5 cardiomyoblast-mediated regeneration. Cardiovascular research. 2015;105:44-54. (*corresponding author)
Professional and Research Experience:
2010-2016
Director, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba
1999-2010
Professor of Molecular Imaging
Director, Biomedical Imaging Research Center, University of Fukui, Fukui
1993-1999
Associate Professor
Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto
1983-1993
Assistant Professor, Radioisotopes Research Laboratory
Kyoto University Hospital, Kyoto
Awards and Honors:
The Japanese Society of Nuclear Medicine Award (1994)
The Best Paper Award for Annals of Nuclear Medicine (1996)
The Best Paper Award for Japanese Journal of Nuclear Medicine (1997)
The Best Paper Award for the Journal of Nuclear Cardiology (2000)
Academic activity
Society of Radiopharmaceutical Sciences (Past President)
Society for Molecular Imaging (merged to WMIS now) (Past-President)
World Molecular Imaging Society (Fellow)
Federation of Asian Societies for Molecular Imaging (Past-President)
Japanese Society for Molecular Imaging (Founding President)
Japanese Society of Nuclear Medicine (Past Council member)
Selected Publications:
245 peer reviewed papers.
