Glucose metabolism and its signaling in cancer and immune regulation
林慧觀
Hui-Kuan Lin
林慧觀 Hui-Kuan Lin
Director of Prostate Cancer Center
Current Position
Department of Cancer Biology
Wake Forest University School of Medicine
Education
National Taiwan University, Taipei, Taiwan, Taiwan, BS, 1993, Pharmacy
National Taiwan University, Taipei, Taiwan, Taiwan, MS, 1995, Pharmacology
University of Rochester, Rochester, NY, PHD, 2002, Pathology (Cancer Biology)
Curriculum Vitae
Zhang, W., Wang, G., Xu, ZG., Tu, F., Dai, J., Chang, Y., Chen, Y., Lu, Y., Zeng, H., Cai, Z., Han, F., Xu, C., Jin, G., Sun, L., Pan, BS., Lai, SW., Hsu, CC., Xu, J., Chen, Z., Li, HY., Seth P., Hu, J., Zhang, X., Li, H., Lin, HK. Lactate is a natural suppressor of RLR signaling by targeting MAVS. Cell. 2019 Jun 27;178(1):176-189.e15. doi: 10.1016/j.cell.2019.05.003. Epub 2019 May 30.
Wang G, Long J, Gao Y, Zhang. W, HanF, XuC, SunL, YangSC, Lan J, HouZ, CaiZ, Jin G, Hsu CC, Wang YH, Hu J, Chen TY, Li H, Lee MG, Lin HK.SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis. Nat. Cell Biol. 2019 Feb;21(2):214-225.
Chan CH, Morrow JK, Li CF, Gao Y, Jin G, Moten A, Stagg LJ, Ladbury JE, Cai Z, Xu D, Logothetis CJ, Hung MC, Zhang S, Lin HK. Pharmacological Inactivation of Skp2 SCF Ubiquitin Ligase Restricts Cancer Stem Cell Traits and Cancer Progression. Cell 154(3):556-68, 8/2013.
Chan CH, Li CF, Yang WL, Gao Y, Lee SW, Feng Z, Huang HY, Tsai KK, Flores LG, Shao Y, Hazle JD, Yu D, Wei W, Sarbassov D, Hung MC, Nakayama KI, Lin HK. The Skp2-SCF E3 Ligase Regulates Akt Ubiquitination, Glycolysis, Herceptin Sensitivity, and Tumorigenesis. Cell 149(5):1098-111, 5/2012.
Yang WL, Wang J, Chan CH, Lee SW, Campos AD, Lamothe B, Hur L, Grabiner BC, Lin X, Darnay BG, Lin HK. The E3 ligase TRAF6 regulates Akt ubiquitination and activation. Science 325(5944):1134-1138, 8/2009.
林琬琬
Wan-Wan Lin
12:00 - 14:00
科技新知研討會
午餐 科技新知研討會-雷文虎克
徐丞志
Cheng-Chih Richard Hsu
徐丞志 Cheng-Chih Richard Hsu
Current Position
Education
Curriculum Vitae
H.-H. Chung, C.-Y. Kao, T.-S. A. Wang, J. Chu, J.-Y. Pei,* C.‐C. Hsu,* “Reaction Tracking and High-throughput Screening of Active Compounds in Combinatorial Chemistry by Tandem Mass Spectrometry Molecular Networking.” Anal. Chem. 2021, 93, 2456-2463.
C.-Y. Weng, T.-H. Kuo, L.M.X. Chai, H.-B. Zou, T.-H. Feng, Y.-J. Huang, J.C. Tsai, P.-H. Wu, Y.-W. Chiu, E. Lan, L.-Y. Sheen, C.-C. Hsu,* “Rapid Quantification of Gut Microbial Short-Chain Fatty Acids by pDART-MS.” Anal. Chem. 2020, 92, 14892-14897.
P. Huang, C.-Y. Huang, T.-C. Lin, L.-E. Lin, E. Yang, C. Lee,* C.-C. Hsu,* P.-T. Chou,* “Towards the Rational Design of Universal Dual Polarity Matrix for MALDI Mass Spectrometry.” Anal. Chem. 2020, 92, 7139-7145.
Y.-C. Huang, H.-H. Chung, E.P. Dutkiewicz, C.-L. Chen, H.-Y. Hsieh, B.-R. Chen, M.-Y. Wang,* C.-C. Hsu,* “Predicting Breast Cancer by Paper Spray Ion Mobility Spectrometry Mass Spectrometry and Machine Learning.” Anal. Chem. 2020, 92, 1653-1657. (featured as the Front Cover)
Communication between cancer cells and immune cells during tumor progression
楊慕華
Muh-Hwa Yang
楊慕華 Muh-Hwa Yang
Chair professor of Institute of Clinical Medicine, Yang Ming Chiao Tung University
Current Position
Institute of Clinical Medicine, National Yang Ming Chiao Tung University
Education
M.D., National Yang-Ming University
Ph.D., National Yang-Ming University
Resident and clinical fellow of Division of Hematology-Oncology, Taipei Veterans General Hospital
Curriculum Vitae
Chen HY, Hsieh, CH, Lin PH, Chen YT, Hsu DS, Tai SK, Chu PY, Yang MH*. Snail regulated microRNA-21 suppresses NLRP3 inflammasome activity to enhance cisplatin resistance. J Immunother Cancer 2022;10:e004832.
Ou DL, Chen CW, Hsu CL, Chung CH, Feng ZR, Lee BS, Cheng AL, Yang MH*, Hsu C*. Regorafenib enhances antitumor immunity via inhibition of p38 kinase/Creb1/Klf4 axis in tumor-associated macrophages. J Immunother Cancer 2021;9:e001657.
Liao TT, Lin CC, Jiang JK, Yang SH, Teng HW, Yang MH*. Harnessing stemness and PD-L1 expression by AT-rich interaction domain-containing protein 3 in colorectal cancer. Theranostics 2020;10:6095-6112.
Li CF, Chen JY, Ho YH, Hsu WH, Wu, LC, Lan HY, Hsu DS, Tai SK, Chang YC*, Yang MH*. Snail-induced claudin-11 prompts collective migration for tumor progression. Nat Cell Biol 2019;21:251-262.
Hwang WL*, Lan HY, Cheng WY, Huang SC, Yang MH*. Tumor stem-Like cells-derived exosomal RNAs prime neutrophils for facilitating tumorigenesis of colon cancer. J Hematol Oncol 2019;12:10.
鄭子豪
TH Cheng
14:30 - 15:30
學會特別演講
ER Protein TXNDC5 as a Novel Therapeutic Target against
Organ Fibrosis and Atherosclerosis
楊鎧鍵
Kai-Chien Yang
楊鎧鍵 Kai-Chien Yang
Professor, Graduate Institute of Pharmacology, National Taiwan University
Current Position
Graduate Institute and Department of Pharmacology, NTU
Division of Cardiology, Department of Internal Medicine, NTU Hospital
Education
1994-2000 M.D. National Taiwan University, Taipei, Taiwan
2003-2005 M.Sc., Medical Sciences, National Taiwan University, Taipei, Taiwan
2007-2012 Ph.D., Molecular Genetics and Genomics, Division of Biology and
Biomedical Sciences, Washington University, St Louis, MO
Curriculum Vitae
CT Hung, TH Su, YT Chen, YF Wu, YT Chen, SJ Lin, SL Lin, KC Yang*. Targeting ER Protein TXNDC5 in Hepatic Stellate Cell Mitigates Liver Fibrosis by Repressing Non-Canonical TGFb Signaling. Gut 2022 Sep;71(9):1876-1891. (Corresponding author)
CF Yeh, SH Cheng, YS Lin, TP Shentu, RT Huang, J Zhu, YT Chen, S Kumar, MS Lin, HL Kao, PH Huang, E Rosello-Sastre, F Garcia, H Jo, Y Fang*, KC Yang*. Targeting Mechano-sensitive Endothelial TXNDC5 to Stabilize eNOS and Reduce Atherosclerosis in vivo. Science Advances 2022 Jan 21; 8(3):eabl8096 (Co-corresponding author)
YT Chen, PY Jhao, CT Hung, YF Wu, SJ Lin, WC Chiang, SL Lin, KC Yang*. Endoplasmic Reticulum Protein TXNDC5 Promotes Renal Fibrosis by Enforcing TGFb Signaling in Kidney Fibroblasts. Journal of Clinical Investigation 2021 Mar 1; 131(5): e143645. (Corresponding author) [Commented in: J Clin Invest. 2021;131(5):e144803]
TH Lee, CF Yeh, YT Lee, YC Shih, YT Chen, CT Hung, MY You, PC Wu, TP Shentu, RT Huang, YS Lin, YF Wu, SJ Lin, FL Lu, PN Tsao, TH Lin, SC Lo, YS Tseng, WL Wu, CN Chen, CC Wu, SL Lin, AI Sperling, RD Guzy, Y Fang, KC Yang*. Fibroblast-enriched Endoplasmic Reticulum Protein TXNDC5 Promotes Pulmonary Fibrosis by Augmenting TGFb Signaling through TGFBR1 Stabilization. Nature Communications 2020 Aug 26; 11(1):4254. (Corresponding author).
YC Shih, CL Chen, Y Zhang, RL Mellor, EM Kanter, Y Fang, HC Wang, CT Hung, JY Nong, Chen HJ, TH Lee, YS Tseng, CN Chen, CC Wu, SL Lin, KA Yamada, JM Nerbonne, KC Yang*. Endoplasmic Reticulum-Resident Protein TXNDC5 Augments Myocardial Fibrosis by Facilitating Extracellular Matrix Protein Folding and Redox-Sensitive Cardiac Fibroblast Activation. Circulation Research 2018; 122(8):1052-1068 (Corresponding author).
林琬琬
Wan-Wan Lin
14:30 - 16:40
致德堂
大會主題論文競賽
15:30 - 15:40
Café Break
15:40 - 16:40
會員大會
學會研究獎項 頒獎
Time / 時間
Topic / 主題
Speaker / 講員
Moderator / 座長
Abstract / 摘要
09:10 - 09:44
聯合學術研討會—藥理與毒物學會蛇毒蛋白毒理、藥理、藥物研發和其應用
Application of proteomic technologies in the development of novel antivenom against cobrabite envenoming
宋旺洲
Wang-Chou Sung
宋旺洲 Wang-Chou Sung
Associate Investigator 副研究員
Current Position
National Health Research Institutes
Education
PhD degree in National Cheng-Kung University, Taiwan/ Protein Chemistry and Immunology.
Curriculum Vitae
Ho Phin Chong, Kae Yi Tan, Bing-Sin Liu, Wang-Chou Sung*, and Choo Hock Tan*, Cytotoxicity of Venoms and Cytotoxins from Asiatic Cobras (Naja kaouthia, Naja sumatrana, Naja atra) and Neutralization by Antivenoms from Thailand, Vietnam, and Taiwan, Toxins, 2022, 14,334.
Bing-Sin Liu, Bo-Rong Jiang, Kai-Chieh Hu, Chien-Hsin Liu, Wen-Chin Hsieh, Min-Han Lin and Wang-Chou Sung, Development of a broad spectrum antiserum against cobra venoms using recombinant three-finger toxins, Toxins, 2021, 13, 556.
Hsuan-Wei Huang, Bing-Sin Liu, Kun-Yi Chien, Liao-Chun Chiang, Sheng-Yu Huang, Wang-Chou Sung*, Wen-Guey Wu*, “Cobra venom proteome and glycome determined from individual snakes of Naja atra reveal medically important dynamic range and systematic geographic variation”,J. Proteomics, 2015, 128, 92-104.
黃德富
Tur-Fu, Huang
李志恒
Jih-Heng Li
09:44 - 10:18
聯合學術研討會—藥理與毒物學會蛇毒蛋白毒理、藥理、藥物研發和其應用
臺灣毒蛇咬傷現況並深入描述青竹絲咬傷凝血病變
Snake envenomation in TW and perspectives on Trimeresurus stejnegeri bite related coagulopathy
毛彥喬
Yan-Chiao Mao
毛彥喬 Yan-Chiao Mao
Director of Clinical Toxicology, Department of Emergency Medicine, Taichung Veterans General Hospital 臺中榮民總醫院臨床毒物科醫師
Current Position
1. Division of Clinical Toxicology, Department of Emergency Medicine, Taichung Veterans General Hospital
2. School of Medicine, National Defense Medical Center
3. College of Medicine, National Chung Hsing University
4. PhD Program in Medical Biotechnology, School of Medical Laboratory Science and Biotechnology, Taipei Medical University
Education
1. MD, National Defense Medical Center
2. MD, Institute of Environmental and Occupational Health Sciences, National Yang-Ming University
3. PhD, Institute of Environmental and Occupational Health Sciences, National Yang-Ming University
4. Student, PhD program in Medical Biotechnology, Taipei Medical University
Curriculum Vitae
1. Chiang L-C, Chien K-Y, Su H-Y, et al. Comparison of Protein Variation in Protobothrops mucrosquamatus Venom between Northern and Southeast Taiwan and Association with Human Envenoming Effects. Toxins. 2022;14(9):643 (共同通信作者)
2. Lai C-S, Liu P-Y, Lee C-H, et al. The development of surgical risk score and evaluation of necrotizing soft tissue infection in 161 Naja atra envenomed patients. PLOS Neglected Tropical Diseases. 2022;16(2):e0010066 (通信作者)
3. Mao Y-C, Chuang H-N, Shih C-H, et al. An investigation of conventional microbial culture for the Naja atra bite wound, and the comparison between culture-based 16S Sanger sequencing and 16S metagenomics of the snake oropharyngeal bacterial microbiota. PLOS Neglected Tropical Diseases. 2021;15(4):e0009331. (共同第一作者)
4. Mao Y-C, Liu P-Y, Chiang L-C, et al. Clinical manifestations and treatments of Protobothrops mucrosquamatus bite and associated factors for wound necrosis and subsequent debridement and finger or toe amputation surgery. Clinical Toxicology. 2020:1-10. (第一作者)
5. Chiang L-C, Tsai W-J, Liu P-Y, et al. Envenomation by Trimeresurus stejnegeri stejnegeri: clinical manifestations, treatment and associated factors for wound necrosis. Journal of Venomous Animals and Toxins including Tropical Diseases. 2020;26. (通信作者)
黃德富
Tur-Fu, Huang
李志恒
Jih-Heng Li
10:18 - 10:52
聯合研討會—藥理與毒物學會蛇毒蛋白毒理、藥理、藥物研發和其應用
The potential application of disintegrins in arterial thrombosis and ischemic inflammatory diseases
黃德富
Tur-Fu, Huang
黃德富 Tur-Fu, Huang
Current Position
Department of Medicine, Mackay Medical College & Graduate Institute of Pharmacology, College of Medicine, National Taiwan University
Yu-Ju Kuo, Yao Tsung Chang, Ching-Hu Chung, Woei-Jer Chuang, Tur-Fu Huang*. Improved antithrombotic activity and diminished bleeding side effect of a pegylated αIIbβ3 antagonist, Disintegrin. Toxins. 12:e426-e426, 2020.
Yu-Ju Kuo, Ching-Hu Chung, Tzu-Yu Pan, Woei-Jer Chuang, Tur-Fu Huang*. A novel αIIbβ3 antagonist from snake venom prevents thrombosis without causing bleeding. Toxins. 12:e11-e11, 2019.
Sung PS, Huang TF, Hsieh SL. Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2. Nature Communications. 3:2402-2402, 2019.
Kuo, Y.J., Chen,Y.R., Hsu, C.C., Peng, H.C., Huang, T.F.*. An αIIbβ3 antagonist prevents thrombosis without causing FcγRIIa-mediated thrombocytopenia. Journal of Thrombosis and Hemostasis. 15:2230-2244, 2017.
Chang, C.H., Chung, C.H., Tu, Y.S., Tsai, C.C., Hsu, C.C., Peng, H.C., Tseng, Y.J., Huang, T.F.*. Trowaglerix venom polypeptides as a novel antithrombotic agent by targeting immunoglobulin-Like domains of glycoprotein VI in platelet highlights. Arterioscler Thromb Vasc Biol. 37:1307-1314, 2017.
黃德富
Tur-Fu, Huang
李志恒
Jih-Heng Li
10:52 - 11:26
聯合研討會—藥理與毒物學會蛇毒蛋白毒理、藥理、藥物研發和其應用
Design of Integrin-specific Disintegrin for treating retinal diseases
莊偉哲
Woei-Jer Chuang
莊偉哲 Woei-Jer Chuang
National Cheng Kung University Senior Vice President/國立成功大學 助理副校長
Current Position
Department of Biochemistry and Molecular Biology, National Cheng Kung University College of Medicine, Tainan, Taiwan.
Education
Ph.D., Department of Chemistry, Florida State University,
Curriculum Vitae
Chen, Y.-C., Chang, Y.-T., Chen, C.-Y., Shiu, J.-H., Cheng, C.-H., Huang, C.-H., Chen, J.-F., and Chuang, W.-J.* (2020) “Structural insight into integrin recognition and anticancer activity of echistatin”, Toxins, 12, 709.
Chang, Y.-S., Shiu, J.-H., Jeng, W.-Y., Chen, C.-Y., Chen, Y.-C., Chang, Y.-T., Huang, C.-H., and Chuang, W.-J.* (2017) “Effects of the RGD loop and C-terminus of rhodostomin on regulating integrin αIIbβ3 recognition”, PLoS One, 12, e0175321.
黃德富
Tur-Fu, Huang
李志恒
Jih-Heng Li
11:26 - 12:00
聯合研討會—藥理與毒物學會蛇毒蛋白毒理、藥理、藥物研發和其應用
Explore the novel function of ADAM9 in cancer progression
佘玉萍
Yuh-Pyng Sher
佘玉萍 Yuh-Pyng Sher
Professor 教授
Current Position
China Medical University
Education
PH.D: Institute of Molecular Medicine, College of Medicine, National Taiwan University
Curriculum Vitae
1. Lin YS, Kuo TT, Lo CC, Cheng WC, Chang WC, Tseng GC, Bai ST, Huang YK, Hsieh CY, Hsu HS, Jiang YF, Lin CY, Lai LC, Li XG, and Sher YP*. ADAM9 functions as a transcriptional regulator to drive angiogenesis in esophageal squamous cell carcinoma. International Journal of Biological Sciences 17(14): 3898-3910, September 7, 2021.
2. Cheng WC, Chang CY, Lo CC, Hsieh CY, Kuo TT, Tseng GC, Wong SC, Chiang SF, Huang KCY, Lai LC, Lu TP, Chao KSC*, and Sher YP*. Identification of theranostic factors for patients with metastasis in early-stage lung adenocarcinoma. Theranostics 11(8):3661-3675. January 26, 2021.
3. Chou CW, Huang YK, Kuo TT, Liu JP, Sher YP*. An Overview of ADAM9: Structure, Activation, and Regulation in Human Diseases. International Journal of Molecular Sciences 21:7790. October 21, 2020.
4. Lin CC, Huang YK, Cho CF, Lin YS, Lo CC, Kuo TT, Tseng GC, Cheng WC, Chang WC, Hsiao TH, Lai LC, Shih JY, Liu YH, Chao KSC, Hsu JL, Lee PC, Sun X, Hung MC, Sher YP*. Targeting positive feedback between BASP1 and EGFR as a therapeutic strategy for lung cancer progression. Theranostics 10(24):10925-10939. August 29, 2020.
5. Lin CY, Chen HJ, Huang CC, Lai LC, Lu TP, Tseng GC, Kuo TT, Kuok QY, Hsu JL, Sung SY, Hung MC*, Sher YP*. ADAM9 promotes lung cancer metastases to brain by a plasminogen activator-based pathway. Cancer Research 74(18):5229-43. September 2014
黃德富
Tur-Fu, Huang
李志恒
Jih-Heng Li
11:30 - 13:30
午餐 壁報論文展示
13:40 - 14:10
聯合研討會—生理與藥理學會代謝疾病
Risk Factors for Diabetes, Sarcopenia, and Chronic Kidney Disease- Advanced Glycation End Products and Acrolein
劉興華
Shing-Hwa Liu
劉興華 Shing-Hwa Liu
Professor 教授
Current Position
Institute of Toxicology, College of Medicine, National Taiwan University
Education
Ph.D.,1991 Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
M.S., 1986 Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
B.S., 1984 School of Pharmacy, College of Pharmacy, China Medical University, Taichung, Taiwan
Curriculum Vitae
Chiu HC, et al. A ubiquitous endocrine disruptor tributyltin induces muscle wasting and retards muscle regeneration. J Cachexia Sarcopenia Muscle. 2022 Nov 16. Epub ahead of print.
Lin CY, et al. Therapeutic ultrasound halts progression of chronic kidney disease in vivo via the regulation of markers associated with renal epithelial-mesenchymal transition and senescence. Int J Mol Sci. 2022 Nov 2;23(21):13387.
Liu SH, et al. Fish Oil Enriched n-3 Polyunsaturated fatty acids improve ketogenic low-carbohydrate/high-fat diet-caused dyslipidemia, excessive fat accumulation, and weight control in rats. Nutrients. 2022 Apr 25;14(9):1796.
Chen HJ, et al. Adverse effects of acrolein, a ubiquitous environmental toxicant, on muscle regeneration and mass. J Cachexia Sarcopenia Muscle. 2019 Feb;10(1):165-176.
Huang KH, et al. Role of Calbindin-D28k in diabetes-associated advanced glycation end-products-induced renal proximal tubule cell injury. Cells. 2019 Jun 30;8(7):660.
羅怡卿
Lo, Yi-Ching
14:10 - 14:40
聯合研討會—生理與藥理學會代謝疾病
Drug Discovery and Metabolic Functions of G Protein-coupled Receptors
洪明秀
Ming-Shiu Hung
洪明秀 Ming-Shiu Hung
Investigator and Associate Director 研究員暨副所長
Current Position
Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Taiwan
Education
B.S. National Taiwan University, Taiwan
M.S. National Sun Yat-sen University, Taiwan
Ph.D. Rutgers University, New Jersey, USA
Curriculum Vitae
Hsiao, W.C., et al.Modulating the affinity and signaling bias of cannabinoid receptor 1 antagonists. Bioorg. Chem. 130:106236 (2023)
Yeh, T.K. et al.Discovery and development of a novel N-(3-bromophenyl)- {[(phenylcarba moyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design. Eur. J. Med. Chem. 229:114043, 2022.
Yeh, Y.N. et al. A structure-function approach identifies L-PGDS as a mediator responsible for glucocorticoid-induced leptin expression in adipocytes. Biochem. Pharmacol. 166: 203-211, 2019.
Chang, C.P., et al. Fluorine-18 isotope labeling for positron emission tomography imaging. Direct evidence for DBPR211 as a peripherally restricted CB1 inverse agonist. Bioorg. Med. Chem. 27: 216-223, 2019.
羅怡卿
Lo, Yi-Ching
14:40 - 14:50
Café Break
14:50 - 15:20
聯合研討會—生理與藥理學會代謝疾病
Role of FKBP51 on development of obesity-associated metabolic disorders
阮琪昌
Chi-Chang Juan
阮琪昌 Chi-Chang Juan
Professor 教授
Current Position
Institute of Physiology, College of Medicine, National Yang Ming Chiao Tung University
Education
Ph.D. in Physiology, National Yang-Ming University, Taipei, Taiwan, 1998.
M.S. in Physiology, National Yang-Ming University, Taipei, Taiwan, 1993.
B.S. in Biology, Tunghai University, Taichung, Taiwan, 1991.
Curriculum Vitae
Endothelin-1 induces lipolysis through activation of the GC/cGMP/Ca2+/ERK/CaMKIII pathway in 3T3-L1 adipocytes. Biochim Biophys Acta Mol Cell Biol Lipids. 1867: 159071, 2022.
Nitric oxide mobilizes intracellular Zn2+ via the GC/cGMP/PKG signaling pathway and stimulates adipocyte differentiation. Int J Mol Sci. 23: 5488, 202
Increased regulated on activation, normal T-cell expressed and secreted levels and cysteine-cysteine chemokine receptor 5 upregulation in omental adipose tissue and peripheral blood mononuclear cells are associated with testosterone level and insulin resistance in polycystic ovary syndrome. Fertil Steril. 116: 1139, 2021.
Curcumin attenuates adipogenesis by inducing preadipocyte apoptosis and inhibiting adipocyte differentiation. Nutrients. 11: 2307, 2019.
李宗玄
Tzong-Shyuan Lee
15:20 - 15:50
聯合研討會—生理與藥理學會代謝疾病
New target in the treatment of obesity – associated metabolic syndrome and type 2 diabetes: The CCR5-mediated signaling
謝博軒
Po-Shiuan Hsieh
謝博軒 Po-Shiuan Hsieh
Professor 教授
Current Position
Department of Physiology and Biophysics, National Defense Medical Center, Taipei, Taiwan
Education
1982-89 M.D. (Medical Degree) National Defense Medical Center (NDMC), Taipei, Taiwan
1994-99 Ph.D. Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, USA
Curriculum Vitae
1. Chan, Pei-Chi, Chieh-Hua Lu, Hung-Che Chien, Yu-Feng Tian, and Po-Shiuan Hsieh*. (2022, Nov). Adipose Tissue-Derived CCL5 Enhances Local ProInflammatory Monocytic MDSCs Accumulation and Inflammation via CCR5 Receptor in High-Fat Diet-Fed Mice. International Journal of Molecular Sciences , 23, 22: 14226.
2. Chan, Pei-Chi, and Po-Shiuan Hsieh* (2022, Aug). The Role and Regulatory Mechanism of Brown Adipose Tissue Activation in Diet-Induced Thermogenesis in Health and Diseases . International Journal of Molecular Sciences, 23,16: 9448.
4. Pei-Chi Chan, Po-Shiuan Hsieh* (2021, Dec). The chemokine systems at the crossroads of inflammation and energy metabolism in the development of obesity. International Journal of Molecular Science, 2021; 22(24):13528.
5. Pei-Chi Chan, Min-Tser Liao, Chieh-Hua Lu, Yu-Feng Tian, Po-Shiuan Hsieh* (2021, Jan). Targeting inhibition of CCR5 on improving obesity-associated insulin resistance and impairment of pancreatic insulin secretion in high fat-fed rodent models. European Journal of Pharmacology, 891, 2021, 173703.
