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Today Bio. Volume 15, June 2022, 100326
in Biology and Medicine. Volume 143, April 2022, 105300
Today Bio. Volume 14, March 2022, 100253
Materials Today. Volume 26, March 2022
Communications Biology. 2022 Jan 19;5(1):70.
Pablo A, Hoofnagle AN, Mathias PC. Listening to your mass spectrometer: An open-source toolkit to visualize mass spectrometer data. (2021) J Mass Spectrom Adv Clin Lab. 23:44-49.
Huang D, Chowdhury S, Wang H, Savage SR, Ivey RG, Kennedy JJ, Whiteaker JR, Lin C, Hou X, Oberg AL, Larson MC, Eskandari N, Delisi DA, Gentile S, Huntoon CJ, Voytovich UJ, Shire ZJ, Yu Q, Gygi SP, Hoofnagle AN, Herbert ZT, Lorentzen TD, Calinawan A, Karnitz LM, Weroha SJ, Kaufmann SH, Zhang B, Wang P, Birrer MJ, Paulovich AG. (2021) Multiomic analysis identifies CPT1A as a potential therapeutic target in platinum-refractory, high-grade serous ovarian cancer. Cell Rep Med. 2(12):100471.
Hsu S, Zelnick LR, Lin YS, Best CM, Kestenbaum BR, Thummel KE, Hoofnagle AN, de Boer IH. (2022) Validation of the 24,25-dihydroxyvitamin D3 to 25-hydroxyvitamin D3 ratio as a biomarker of 25-hydroxyvitamin D3 clearance. J Steroid Biochem Mol Biol. 217:106047.
Hsu S, Prince DK, Williams K, Allen NB, Burke GL, Hoofnagle AN, Li X, Liu KJ, McClelland RL, Michos ED, Psaty BM, Shea SJ, Rice KM, Rotter JI, Siscovick D, Tracy RP, Watson KE, Kestenbaum BR, de Boer IH. Clinical and biomarker modifiers of vitamin D treatment response: the Multi-Ethnic Study of Atherosclerosis. Am J Clin Nutr. 115(3):914-924.
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Complete Publication List
Lisci M and Griffiths GM
Arming a killer: mitochondrial regulation of CD8+ T cell cytotoxicity
Trends in Cell Biology (2022) S0962-8924
Lisci M, Barton PR, Randzavola LO, Ma CY, Marchingo J, Cantrell DA, Paupe V, Prudent J, Stinchcombe
JC, Griffiths GM
Mitochondrial translation is required for sustained killing by cytotoxic T cells
Science (2021) 374(6565): eabe9977
Richard AC, Frazer GL, Ma CY, Griffiths GM
Staggered starts in the race to T cell activation
Trends in Immunology (2021) 42:994-1008
Frazer G, Gawden-Bone C, Dieckmann N, Asano Y, Griffiths GM
Signal strength controls the rate of polarization within CTLs during killing
J Cell Biol (2021) 220 (10): e202104093.
Douanne T, Stinchcombe JC, Griffiths GM
Teasing out function from morphology: Similarities between primary cilia and immune synapses.
J Cell Biol. 2021 220(6): e202102089. doi: 10.1083/jcb.202102089.
Douanne, T and Griffiths GM
Cytoskeletal control of the secretory immune synapse Current Opinions in Cell Biology 71:87-94 (2021)
Griscelli Syndrome Type 2 Sine Albinism: Unraveling Differential RAB27A Effector Engagement.
Ohishi Y, Ammann S, Ziaee V, Strege K, Groß M, Amos CV, Shahrooei M, Ashournia P, Razaghian A, Griffiths
GM, Ehl S, Fukuda M, Parvaneh N.
Front Immunol. 2020 11:612977. doi: 10.3389/fimmu.2020.612977.
A new direction for Traffic.
Marks MS, Parton RG, Schroer TA, Tooze SA, Brodsky FM, Marsh M, Schmid SL, Griffiths GM, Stevens TH,
van Meer G.
Traffic. 2020 21:724. doi: 10.1111/tra.12763.
CT Hung, TH Su, YT Chen, YF Wu, YT Chen, SJ Lin, SL Lin, KC Yang*. Targeting ER Protein TXNDC5 in Hepatic Stellate Cell Mitigates Liver Fibrosis by Repressing Non-Canonical TGFb Signaling. Gut 2022 Sep;71(9):1876-1891. (Corresponding author)
CF Yeh, SH Cheng, YS Lin, TP Shentu, RT Huang, J Zhu, YT Chen, S Kumar, MS Lin, HL Kao, PH Huang, E Rosello-Sastre, F Garcia, H Jo, Y Fang*, KC Yang*. Targeting Mechano-sensitive Endothelial TXNDC5 to Stabilize eNOS and Reduce Atherosclerosis in vivo. Science Advances 2022 Jan 21; 8(3):eabl8096 (Co-corresponding author)
YT Chen, PY Jhao, CT Hung, YF Wu, SJ Lin, WC Chiang, SL Lin, KC Yang*. Endoplasmic Reticulum Protein TXNDC5 Promotes Renal Fibrosis by Enforcing TGFb Signaling in Kidney Fibroblasts. Journal of Clinical Investigation 2021 Mar 1; 131(5): e143645. (Corresponding author) [Commented in: J Clin Invest. 2021;131(5):e144803]
TH Lee, CF Yeh, YT Lee, YC Shih, YT Chen, CT Hung, MY You, PC Wu, TP Shentu, RT Huang, YS Lin, YF Wu, SJ Lin, FL Lu, PN Tsao, TH Lin, SC Lo, YS Tseng, WL Wu, CN Chen, CC Wu, SL Lin, AI Sperling, RD Guzy, Y Fang, KC Yang*. Fibroblast-enriched Endoplasmic Reticulum Protein TXNDC5 Promotes Pulmonary Fibrosis by Augmenting TGFb Signaling through TGFBR1 Stabilization. Nature Communications 2020 Aug 26; 11(1):4254. (Corresponding author).
YC Shih, CL Chen, Y Zhang, RL Mellor, EM Kanter, Y Fang, HC Wang, CT Hung, JY Nong, Chen HJ, TH Lee, YS Tseng, CN Chen, CC Wu, SL Lin, KA Yamada, JM Nerbonne, KC Yang*. Endoplasmic Reticulum-Resident Protein TXNDC5 Augments Myocardial Fibrosis by Facilitating Extracellular Matrix Protein Folding and Redox-Sensitive Cardiac Fibroblast Activation. Circulation Research 2018; 122(8):1052-1068 (Corresponding author).
Jiang N, Xie B, Xiao W, Fan M, Xu S, Duan Y, Hamsafar Y, Evans AC, Huang J, Zhou W, Lin X, Ye N, Wanggou S, Chen W, Jing D, Fragoso RC, Dugger BN, Wilson PF, Coleman MA, Xia S, Li X, Sun LQ, Monjazeb AM, Wang A, Murphy WJ, Kung HJ, Lam KS, Chen HW, Li JJ. Fatty acid oxidation fuels glioblastoma radioresistance with CD47-mediated immune evasion Nat Commun. Mar 21;13(1):1511. (2022)
Chen CL, Hsu SC, Chung TY, Chu CY, Wang HJ, Hsiao PW, Yeh SD, Ann DK, Yen Y, Kung HJ. Arginine is an epigenetic regulator targeting TEAD4 to modulate OXPHOS in prostate cancer cells. Nat Commun (2021) 12:2398
Tseng LL, Cheng HH, Yeh TS, Huang SC, Syu YY, Chuu CP, Yuh CH, Kung HJ, Wang WC. Targeting the histone demethylase PHF8-mediated PKCα-Src-PTEN axis in HER2-negative gastric cancer. Proc Natl Acad Sci U S A. (2020) 117:24859
Yang CP, Yang WS, Wong YH, Wang KH, Teng YC, Chang MH, Liao KH, Nian FS, Chao CC, Tsai JW, Hwang WL, Lin MW, Tzeng TY, Wang PN, Campbell M, Chen LK, Tsai TF, Chang PC, Kung HJ. Muscle atrophy-related myotube-derived exosomal microRNA in neuronal dysfunction: Targeting both coding and long noncoding RNAs. Aging Cell. 19(5):e13107. (2020)
1. Shih Hsien Lin1, Mei Hung Chi1, I. Hui Lee1, Kao Chin Chen1, Ying Chun Tai1, Wei Jen Yao1, Nan Tsing Chiu1, Dong Yu Yang1, Chun Yu Lin1, Po See Chen1, Yen Kuang Yang, 2021, A pilot study on the association between the blood oxygen level-dependent signal in the reward system and dopamine transporter availability in adults with attention deficit hyperactivity disorder. CNS Spectrums,
2. Dom-Gene Tu, Hsuan-Yu Chen1, Wei Jen Yao, 2021, Verification of the Efficacy of New Diagnostic Criteria for Retropharyngeal Nodes in a Cohort of Nasopharyngeal Carcinoma Patients. International Journal of Medical Sciences (Ivyspring International Publisher)-Vol. 18, Iss: 15, pp 3463-3469.
3. Ying Chun Tai1, Mei Hung Chi1, Ching Lin Chu1, Nan Tsing Chiu1, Wei Jen Yao1, Po See Chen1, Yen Kuang Yang, 2019, Availability of Striatal Dopamine Transporter in Healthy Individuals With and Without a Family History of ADHD, Journal of Attention Disorders (SAGE Publications)-Vol. 23, Iss: 7, pp 665-670
Dr. Chia-Ning Shen is currently a research fellow in the Genomics Research Center, Academia Sinica, Taiwan. Dr. Shen earned his PhD from Developmental Biology Program, Department of Biology and Biochemistry, University of Bath, United Kingdom in 2002. From 2002 to 2004, Dr. Shen worked as a research officer in the Centre for Regenerative Medicine in University of Bath. Dr. Shen came back to Taiwan and joined the Genomics Research Center of Academia Sinica in the summer of 2004. Dr. Shen's research interest primarily focuses on two fields, cancer stem cells and regenerative medicine. He currently focuses on investigating mechanisms involved in naturally occurring somatic cell reprogramming. Based dissecting the basis of cell differentiation and transdifferentiation, Dr. Shen aims to develop methodologies to trigger tissue regeneration and to identify the initial factors for neoplastic transformation in somatic cells. For example, Dr Shen is applying organoid technologies to dissect cancer causes and to develop precision medicinal strategies. As of today, Dr. Shen has published over 90 articles in world-renowned journals which have been cited for more than 3600 times.
Dr. Shen had spared time to attend several training courses. In 2008, he has completed the course program in legal studies in National Taiwan University. In 2012, he also attended the international training program of Multidisciplinary Management of Technology in National Cheng-Chi University. Aside from conducting research, Dr. Shen has also been responsible for coordinating academic activities and overseeing administrative work at the Genomics Research Center as the Deputy Director from 2013 to 2019. He has also served as Acting Division Director of Biotechnology Incubation Center in the Genomics Research Center for incubating biotechnology companies that licensed technologies from Academia Sinica. Dr. Shen joined Biomedical Translation Research Center in September 201. From 2019-2022, Dr. Shen served as CEO of BioHub Taiwan (Innovation & Incubation Center, Biomedical Translation Research Center) to establish Biotech Ecosystem and to incubate biotech startups at National Biotechnology Research Park. Currently, Dr. Shen is a chief PI managing the core facilities for translational medicine at National Biotechnology Research Park.
Dr. Shen was involved in the establishment of Taiwan Society for stem cell research (TSSCR) in 2005 aiming at providing opportunities for close interactions among stem cell researchers in Taiwan. Dr. Shen has been served as TSSCR president from 2017 to 2021 to cooperates with the government to implement relevant cell therapy legislation and policies. Dr. Shen is currently an Executive Supervisor in TSSCR.